Q10 / 200 · MHT CET - Medical 2026 (24 April Shift 2) · Biology
Match the disorders in List I with their causes in List II and choose the correct option.
List I List II (A) Thalassemia. (I) non-disjunction of sex chromosomes. (B) Sickle-cell anaemia. (II) non-disjuction of 21st pair of chromosomes. (C) Turner's Syndrome. (III) Synthesising few globin molecules. (D) Down's Syndrome. (IV) synthesising an incorrectly functional globin.
| List I | List II |
|---|---|
| (A) Thalassemia. | (I) non-disjunction of sex chromosomes. |
| (B) Sickle-cell anaemia. | (II) non-disjuction of 21st pair of chromosomes. |
| (C) Turner's Syndrome. | (III) Synthesising few globin molecules. |
| (D) Down's Syndrome. | (IV) synthesising an incorrectly functional globin. |
- A(A) - (I), (B) - (II), (C) - (III), (D) - (IV).
- B(A) - (II), (B) - (IV), (C) - (I), (D) - (III).
- C(A) - (I), (B) - (II), (C) - (IV), (D) - (III).
- Correct answerD(A) - (III), (B) - (IV), (C) - (I), (D) - (II).
Solution
Thalassemia is a quantitative blood disorder that results in the synthesis of too few globin molecules. Thus, (A) matches (III).
Sickle-cell anaemia is a qualitative blood disorder that results in the synthesis of an incorrectly functioning globin molecule. Thus, (B) matches (IV).
Turner's Syndrome is caused by the absence of one of the X chromosomes ($45$ with $X0$), which occurs due to the non-disjunction of sex chromosomes during gametogenesis. Thus, (C) matches (I).
Down's Syndrome is caused by the presence of an additional copy of chromosome number $21$ (trisomy of $21$), which occurs due to the non-disjunction of the $21$st pair of chromosomes. Thus, (D) matches (II).
The correct matching is (A) - (III), (B) - (IV), (C) - (I), (D) - (II).
Answer: (A) - (III), (B) - (IV), (C) - (I), (D) - (II).
Sickle-cell anaemia is a qualitative blood disorder that results in the synthesis of an incorrectly functioning globin molecule. Thus, (B) matches (IV).
Turner's Syndrome is caused by the absence of one of the X chromosomes ($45$ with $X0$), which occurs due to the non-disjunction of sex chromosomes during gametogenesis. Thus, (C) matches (I).
Down's Syndrome is caused by the presence of an additional copy of chromosome number $21$ (trisomy of $21$), which occurs due to the non-disjunction of the $21$st pair of chromosomes. Thus, (D) matches (II).
The correct matching is (A) - (III), (B) - (IV), (C) - (I), (D) - (II).
Answer: (A) - (III), (B) - (IV), (C) - (I), (D) - (II).
Hence, the correct answer is option: 'D'.