Which of the following chemical substance destroys the neurotransmitter once the impulse has been transferred across the synapse ?

When a nerve impulse reaches the synaptic cleft, neurotransmitters like acetylcholine are released to transmit the signal to the adjacent neuron.

Once the impulse has been successfully transferred, continuous stimulation of the postsynaptic neuron must be prevented. This is achieved by the enzymatic breakdown of the neurotransmitter.

The enzyme cholinesterase (or acetylcholinesterase) is present in the synaptic cleft and specifically breaks down acetylcholine into acetate and choline, thereby destroying the neurotransmitter and terminating the signal.

Answer: Cholinesterase