Q182 / 200 · NEET 2009 (Screening) · Zoology

Sickle cell anaemia is

  • A
    an autosomal linked dominant trait
  • B
    caused by substitution of valine by glutamic acid in the $\beta$-globin chain of haemoglobin
  • Correct answer
    C
    caused by a change in base pair of DNA
  • D
    characterized by elongated sickle like $\mathrm{RBC}$ with a nucleus

Solution

Sickle-cell anaemia is caused by a change in a single base pair of DNA. It is a genetic disease reported from negroes. The individuals of sickle-cell anaemia are immune to malaria.

Hence, the correct answer is option: 'C'.

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