Q174 / 180 · AIIMS 2019 (25 May) · Zoology

Select the correctly matched pair.

  • A
    Cosmid - Cannot be used in human genome project
  • Correct answer
    B
    $\mathrm{BAC}-300-350 \mathrm{~kb}$ of foreign DNA
  • C
    YAC - Can clone fragments upto $45 \mathrm{~kb}$ in length only
  • D
    Phagemid - An RNA based cloning vector carrying an origin of replication derived from adenovirus.

Solution

Bacterial artificial chromosome (BAC) vectors are based on natural, extra-chromosomal plasmid of E.coli. These vectors can accommodate upto $300-350 \mathrm{~kb}$ of foreign DNA and are also being used in genome sequencing project.

Hence, the correct answer is option: 'B'.

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