Scientists find a gene $P$ that helps human peripheral neurons to sense temperature less than $13^{\circ} \mathrm{C}$ and induce a physiological signal of avoidance. This gene is present in almost all vertebrates. Considering that gene $P$ has role only in detection of low temperature, the correct statement(s) is(are) ___.

• Correct answer
  A

  Gene $P$ is beneficial for humans as it warns the body against low temperature.
• Correct answer
  B

  Loss-of-function mutant of gene $\boldsymbol{P}$ most likely survive in ambient temperature in laboratory conditions.
• Correct answer
  C

  Gene $\boldsymbol{P}$ may be lost in fish that live in cold waters.
• D

  Gene $\boldsymbol{P}$ must be hyperactivated in fish that live in cold water.

Hence, the correct answer is options: 'A', 'B', 'C'.