Q43 / 200 · MHT CET - Medical 2026 (23 April Shift 1) · Biology
Insulin production by recombinant DNA technology is designed by -----------------.
- AEdward Sharpey Schafer
- Correct answerBGilbert and Villa-Komaroff
- CItakura et al.
- DStanley Cohen et al
Solution
The production of human insulin using recombinant DNA technology involved specific milestones achieved by various scientists.
Keiichi Itakura and his coworkers chemically synthesized the DNA sequences for the two polypeptide chains, A and B, of human insulin in 1977.
The experimental strategy and design to produce insulin using recombinant DNA technology by transferring the insulin-coding sequence into a bacterial plasmid vector next to a bacterial gene to express a fusion protein was pioneered by Walter Gilbert and Lydia Villa-Komaroff in 1978.
Edward Sharpey Schafer originally suggested the name insulin and linked the islets of Langerhans to diabetes in 1916, whereas Stanley Cohen and Herbert Boyer developed the foundational methods of recombinant DNA technology in 1972.
Therefore, the production of insulin by recombinant DNA technology was designed by Gilbert and Villa-Komaroff.
Answer: Gilbert and Villa-Komaroff
Keiichi Itakura and his coworkers chemically synthesized the DNA sequences for the two polypeptide chains, A and B, of human insulin in 1977.
The experimental strategy and design to produce insulin using recombinant DNA technology by transferring the insulin-coding sequence into a bacterial plasmid vector next to a bacterial gene to express a fusion protein was pioneered by Walter Gilbert and Lydia Villa-Komaroff in 1978.
Edward Sharpey Schafer originally suggested the name insulin and linked the islets of Langerhans to diabetes in 1916, whereas Stanley Cohen and Herbert Boyer developed the foundational methods of recombinant DNA technology in 1972.
Therefore, the production of insulin by recombinant DNA technology was designed by Gilbert and Villa-Komaroff.
Answer: Gilbert and Villa-Komaroff
Hence, the correct answer is option: 'B'.