Q180 / 200 · NEET 2023 (Manipur) · Zoology

In which disorder change of single base pair in the gene for beta globin chain results in change of glutamic acid to valine?

  • A
    Haemophilia
  • B
    Phenylketonuria
  • C
    Thalassemia
  • Correct answer
    D
    Sickle cell anaemia

Solution

Sickle-cell anaemia is caused by mutation of the gene controlling $\beta$-chain of haemoglobin. Due to this mutation, glutamic acid present at $6^{\text {th }}$ position of the $\beta$-chain is replaced by amino acid valine.

Hence, the correct answer is option: 'D'.

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