Q173 / 180 · AIIMS 2001 · Zoology

Assertion : Watson and Crick provided experimental proof of semiconservative nature of DNA relication. Reason : DNA polymerase binds nucleotides in replication.

  • A
    If both Assertion and Reason are true and Reason is the correct explantion of Assertion
  • B
    If both Assertion and Reason are true and Reason is not the correct explanation of Assertion
  • C
    If Assertion is true but Reason is false
  • Correct answer
    D
    If Assertion is false but Reason is true.

Solution

Watson and Crick suggested the double helical structure of DNA. Semiconservative nature of DNA replication was proved by Messelson and Stahl by using heavy isotope of nitrogen $\left({ }^{15} \mathrm{~N}\right)$. DNA polymerase III establishes phosphodiester linkages between the adjacent deoxyribo-nucleoside phosphate in presence of ATP/GTP, TPP and $\mathrm{Mg}^{2+}$. It produces a new strand of DNA. DNA polymerase binds nucleotides in 5'-3' direction.

Hence, the correct answer is option: 'D'.

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